What is hypercalcemia a common finding in?

Hypercalcemia is a common finding in multiple myeloma due to the disease's effects on bone metabolism. In multiple myeloma, malignant plasma cells proliferate in the bone marrow and can lead to bone destruction. This bone resorption results in the release of calcium into the bloodstream, causing elevated calcium levels. Additionally, multiple myeloma can stimulate the production of certain cytokines that promote osteoclast activity, further contributing to the hypercalcemic state.

In contrast, while hypercalcemia can occur in other malignancies such as leukemia and lymphoma, it is particularly prominent in multiple myeloma as part of its characteristic manifestations. The connection between multiple myeloma and hypercalcemia is well-documented, making it a key indicator for diagnosis and management of the disease. Anemia, while frequently associated with multiple myeloma due to bone marrow involvement, is not directly related to hypercalcemia, thus making it an inappropriate choice in this context.